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The cultural shift toward recognizing and treating perimenopausedriven by patient advocacy, social media, and high-profile coveragemeans women are presenting earlier, often in their late 30s and early 40s, with irregular cycles, vasomotor symptoms, sleep disruption, and mood changes

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In contrast, in untreated rats, higher activities of microsomal NADPH-cytochrome c reductase, 7-ethoxycoumarin o-deethylase, 7-ethoxyresorufin o-deethylase, and cytosolic glutathione transferase were found in the centrilobular hepatocytes (Bengtsson et al